Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777836 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL2844733 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21777835 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21773216 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21777837 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21777260 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21773211 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL6616536 | 0.93 | FUCA1 (0.50) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL5071734 | 0.90 | ACHE (0.55) | SIGMAR1DRD2DRD3ACHEBCHE | |
| SCHEMBL4090277 | 0.89 | KDM1A (0.54) | FUCA1SIGMAR1DRD2DRD3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113165992-B | Process for preparing tert-butyl exo-N- (3-azabicyclo [3.2.1] oct-8-yl) carbamate | 豪夫迈·罗氏有限公司 | 2024-08-06 | — | — | CN | claimed |
| CN-113165992-A | Method for producing exo-N- (3-azabicyclo [3.2.1] octan-8-yl) carbamic acid tert-butyl ester | 豪夫迈·罗氏有限公司 | 2021-07-23 | — | — | CN | claimed |
| US-6559162-B2 | Electrophysiological activity | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | claimed |
| US-12275709-B2 | Process for the preparation of exo-tert-butyl N-(3-azabicyclo[3.2.1]octan-8-yl)carbamate | HOFFMANN-LA ROCHE INC. (US) | 2025-04-15 | — | — | US | disclosed |
| CN-113165992-B | Process for preparing tert-butyl exo-N- (3-azabicyclo [3.2.1] oct-8-yl) carbamate | 豪夫迈·罗氏有限公司 | 2024-08-06 | — | — | CN | disclosed |
| EP-3902779-B1 | PROCESS FOR THE PREPARATION EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| EP-3902779-B1 | PROCESS FOR THE PREPARATION EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| US-20220073469-A1 | PROCESS FOR THE PREPARATION OF EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE | HOFFMANN-LA ROCHE INC. (US) | 2022-03-10 | — | — | US | disclosed |
| EP-3902779-A1 | PROCESS FOR THE PREPARATION EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE | F. Hoffmann-La Roche AG (CH) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020136188-A1 | PROCESS FOR THE PREPARATION EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-07-02 | — | — | WO | disclosed |
| WO-2020136188-A1 | PROCESS FOR THE PREPARATION EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-07-02 | — | — | WO | disclosed |
| WO-2007039884-A1 | 3 -AZABICYCLOOCTANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007007281-A2 | MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-18 | — | — | WO | disclosed |
| US-20060276487-A1 | New compounds useful for DPP-IV enzyme inhibition | SANOFI-AVENTIS (FR) | 2006-12-07 | — | — | US | disclosed |
| EP-1664031-A2 | ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS | Sanofi-Aventis (FR) | 2006-06-07 | — | — | EP | disclosed |
| WO-2006056863-A1 | PYRIDO’2, 3-D!PYRIMIDINES AS ANTI-INFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2006-06-01 | — | — | WO | disclosed |
| WO-2005021536-A2 | ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS | SANOFI-AVENTIS (FR) | 2005-03-10 | — | — | WO | disclosed |
| WO-2005021536-A2 | ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS | SANOFI-AVENTIS (FR) | 2005-03-10 | — | — | WO | disclosed |
| US-4719217-A | Certain N-azabicycloalkyl-benzamides useful in the treatment of impaired gastro-intestinal motility or emesis | BEECHAM GROUP P.L.C. (GB) | 1988-01-12 | — | — | US | disclosed |
| EP-0212802-A1 | Substituted benzamides | BEECHAM GROUP PLC (GB) | 1987-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12275709-B2 | Process for the preparation of exo-tert-butyl N-(3-azabicyclo[3.2.1]octan-8-yl)carbamate | HUWE1, APP, PSEN1 | FUCA1 2866/4885SIGMAR1 4618/4885DRD2 1515/4885 |
| US-20220073469-A1 | PROCESS FOR THE PREPARATION OF EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE | HUWE1, APP, PSEN1 | FUCA1 2866/4885SIGMAR1 4618/4885DRD2 1515/4885 |
| US-20060276487-A1 | New compounds useful for DPP-IV enzyme inhibition | DPP4, DPP7, DPP9 | FUCA1 845/4885SIGMAR1 3847/4885DRD2 2579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.