Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536111 | 0.80 | PRKCI (0.53) | DYRK1AHCRTR1HCRTR2DYRK2DYRK1B | |
| SCHEMBL17794412 | 0.80 | DYRK1A (0.46) | DYRK1AHCRTR1HCRTR2DYRK2DYRK1B | |
| SCHEMBL20834640 | 0.77 | TSHR (0.45) | DYRK1AHCRTR1HCRTR2CYP11B1CYP11B2 | |
| SCHEMBL4777483 | 0.77 | HCRTR1 (0.46) | DYRK1AHCRTR1HCRTR2DYRK2DYRK1B | |
| SCHEMBL29786944 | 0.76 | IDO1 (0.50) | DYRK1ADYRK2DYRK1BCYP11B1CYP11B2 | |
| SCHEMBL4009763 | 0.76 | MMP3 (0.82) | MMP3ENPP2USP7FLT3CYP11B1 | |
| SCHEMBL4001097 | 0.76 | MMP3 (0.82) | MMP3ENPP2USP7FLT3CYP11B1 | |
| SCHEMBL27945878 | 0.76 | DYRK1A (0.43) | DYRK1AHCRTR1HCRTR2DYRK2DYRK1B | |
| SCHEMBL4006124 | 0.74 | MMP3 (0.72) | MMP3CDK2GSK3BENPP2USP7 | |
| SCHEMBL30504282 | 0.74 | MMP3 (0.79) | MMP3CDK2GSK3BENPP2USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843724-A1 | BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE | National Health Research Institutes (TW) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047360-A1 | BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2020-03-05 | — | — | WO | disclosed |