Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855931 | 0.82 | SLC6A3 (0.41) | GAASLC6A3ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL15478255 | 0.82 | SLC6A3 (0.38) | GAASLC6A3ALDH1A1RAB9AADRB3 | |
| SCHEMBL2827059 | 0.79 | KDM4E (0.43) | GAASLC6A3ALDH1A1RAB9AADRB3 | |
| SCHEMBL13196362 | 0.78 | SLC6A3 (0.36) | GAASLC6A3RAB9AADRB3FPR3 | |
| SCHEMBL13851715 | 0.77 | SLC6A3 (0.39) | GAASLC6A3RAB9AADRB3FPR3 | |
| SCHEMBL2827987 | 0.77 | GAA (0.56) | HTTGAASLC6A3ALDH1A1RAB9A | |
| SCHEMBL11985523 | 0.77 | GAA (0.36) | GAASLC6A3RAB9AADRB3FPR3 | |
| SCHEMBL13799644 | 0.76 | SMN1; SMN2 (0.44) | HTTGAAALDH1A1LMNACA2 | |
| SCHEMBL14736582 | 0.73 | ALDH1A1 (0.50) | HTTGAAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4919965 | 0.73 | HPGD (0.53) | GAAALDH1A1RAB9ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592073-B1 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND THEIR USE | AERPIO THERAPEUTICS INC (US) | 2017-08-30 | — | — | EP | disclosed |
| US-7973047-B2 | Beta-Secretase modulators and methods of use | AMGEN INC. (US) | 2011-07-05 | — | — | US | disclosed |
| US-20100222338-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. | 2010-09-02 | — | — | US | disclosed |
| WO-2008099165-A1 | PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222338-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | HTT 1878/4885GAA 37/4885SLC6A3 4713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.