Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 11/20 | 0.61 |
| ▸ | MERTK | Q12866 | 11/20 | 0.61 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 2/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.45 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18617188 | 1.00 | AXL (0.61) | AXLMERTKGRM2HDAC1PARP1 | |
| SCHEMBL18615806 | 0.89 | AXL (0.62) | AXLMERTKGRM2HDAC1PARP1 | |
| SCHEMBL18616607 | 0.89 | MERTK (0.65) | AXLMERTKHDAC1BMPR1BBMPR1A | |
| SCHEMBL24838113 | 0.85 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18615840 | 0.85 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616319 | 0.85 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18615785 | 0.84 | AXL (0.64) | AXLMERTKGRM2MELK | |
| SCHEMBL18616317 | 0.83 | ACVR1 (0.56) | AXLMERTKGRM2BMPR1BBMPR1A | |
| SCHEMBL18617176 | 0.83 | MERTK (0.57) | AXLMERTKGRM2BMPR1BBMPR1A | |
| SCHEMBL18616320 | 0.82 | AXL (0.60) | AXLMERTKBMPR1BBMPR1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |