Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 6/20 | 0.62 |
| ▸ | MERTK | Q12866 | 6/20 | 0.62 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | NMT1 | P30419 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21779421 | 0.89 | AXL (0.61) | AXLMERTKGRM2HDAC1JAK2 | |
| SCHEMBL18617188 | 0.89 | AXL (0.61) | AXLMERTKGRM2HDAC1JAK2 | |
| SCHEMBL18615785 | 0.82 | AXL (0.64) | AXLMERTKGRM2PIK3CBMELK | |
| SCHEMBL18616276 | 0.81 | AXL (0.58) | AXLMERTKPIK3CBMELKLRRK2 | |
| SCHEMBL18616607 | 0.79 | MERTK (0.65) | AXLMERTKHDAC1 | |
| SCHEMBL18579792 | 0.78 | AXL (1.00) | AXLMERTK | |
| SCHEMBL19102198 | 0.75 | ATR (0.72) | — | |
| SCHEMBL24838113 | 0.75 | MERTK (0.58) | AXLMERTK | |
| SCHEMBL18616319 | 0.75 | MERTK (0.58) | AXLMERTK | |
| SCHEMBL18615840 | 0.75 | MERTK (0.58) | AXLMERTKPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |