Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.64 |
| ▸ | MERTK | Q12866 | 7/20 | 0.64 |
| ▸ | MELK | Q14680 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21779421 | 0.84 | AXL (0.61) | AXLMERTKMELKGRM2 | |
| SCHEMBL18617188 | 0.84 | AXL (0.61) | AXLMERTKMELKGRM2 | |
| SCHEMBL18615806 | 0.82 | AXL (0.62) | AXLMERTKMELKGRM2PIK3CB | |
| SCHEMBL18579860 | 0.79 | AXL (1.00) | AXLMERTK | |
| SCHEMBL18616607 | 0.75 | MERTK (0.65) | AXLMERTK | |
| SCHEMBL18616305 | 0.74 | AXL (0.59) | AXLMERTKPIK3CB | |
| SCHEMBL18616325 | 0.74 | CHEK2 (0.68) | AXLMERTKCHEK1CHEK2PIK3CB | |
| SCHEMBL18616630 | 0.70 | CHEK2 (0.57) | AXLMERTKCHEK1CHEK2PIK3CB | |
| SCHEMBL5167560 | 0.70 | HDAC1 (0.51) | MELKGRM2MEN1KMT2A | |
| SCHEMBL24838113 | 0.70 | MERTK (0.58) | AXLMERTKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |