SCHEMBL21780058

SCHEMBL21780058

NC/C(=C\F)COc1ccc(C(=O)N2CCc3c(Cl)cccc3C2)cc1F

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
AOC2 O75106 3/20 0.41
NPC1 O15118 1/20 0.40
TRAP1 Q12931 2/20 0.39
ALDH1A1 P00352 2/20 0.39
HPGD P15428 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CPT2 P23786 1/20 0.38
CPT1A P50416 1/20 0.38
AOC3 Q16853 5/20 0.38
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
KCNH2 Q12809 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21780057 1.00 AOC2 (0.41) AOC2NPC1TRAP1ALDH1A1HPGD
Trifluoroacetic Acid SCHEMBL30089527 0.95 AOC2 (0.38) AOC2NPC1TRAP1ALDH1A1HPGD
Trifluoroacetic Acid SCHEMBL21768123 0.95 AOC2 (0.38) AOC2NPC1TRAP1ALDH1A1HPGD
Trifluoroacetic Acid SCHEMBL30089532 0.95 AOC2 (0.38) AOC2NPC1TRAP1ALDH1A1HPGD
Trifluoroacetic Acid SCHEMBL21768136 0.95 AOC2 (0.38) AOC2NPC1TRAP1ALDH1A1HPGD
Trifluoroacetic Acid SCHEMBL21768048 0.95 AOC2 (0.38) AOC2NPC1TRAP1ALDH1A1HPGD
SCHEMBL21780098 0.87 HPGD (0.50) NPC1ALDH1A1HPGDSMN1; SMN2AOC3
SCHEMBL21780093 0.87 HPGD (0.50) NPC1ALDH1A1HPGDSMN1; SMN2AOC3
Trifluoroacetic Acid SCHEMBL30089447 0.83 HPGD (0.45) NPC1ALDH1A1HPGDSMN1; SMN2AOC3
Trifluoroacetic Acid SCHEMBL30089487 0.83 HPGD (0.45) NPC1ALDH1A1HPGDSMN1; SMN2AOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3617186-A1 FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2020-03-04 EP disclosed