Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.61 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.61 |
| ▸ | SCN1A | P35498 | 1/20 | 0.61 |
| ▸ | SCN4A | P35499 | 1/20 | 0.61 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.61 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.61 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.61 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780467 | 0.87 | KCNH2 (0.45) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL22563269 | 0.84 | KCNH2 (0.45) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| Eleclazine SCHEMBL29377130 | 0.76 | KCNH2 (1.00) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| Eleclazine SCHEMBL14480722 | 0.76 | KCNH2 (1.00) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| Eleclazine SCHEMBL16989336 | 0.75 | KCNH2 (0.98) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL14480798 | 0.75 | KCNH2 (0.64) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL14480581 | 0.74 | SCN1A (0.85) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| Eleclazine SCHEMBL16989318 | 0.72 | KCNH2 (0.91) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| Eleclazine SCHEMBL19923836 | 0.71 | KCNH2 (0.84) | KCNH2SCN5ASCN9ASCN1ASCN4A | |
| Eleclazine SCHEMBL16989319 | 0.71 | KCNH2 (0.88) | KCNH2SCN5ASCN9ASCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |