Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 6/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780456 | 0.87 | KCNH2 (0.61) | KCNH2SCN9ASCN1ASCN4ASCN5A | |
| SCHEMBL21780488 | 0.80 | ROCK2 (0.36) | KCNH2ROCK2ROCK1GPR142PIK3CA | |
| SCHEMBL22563248 | 0.78 | TLR8 (0.36) | KCNH2ROCK2ROCK1GPR142PIK3CA | |
| SCHEMBL14480891 | 0.74 | KCNH2 (0.77) | KCNH2SCN9ASCN1ASCN4ASCN5A | |
| SCHEMBL25955585 | 0.74 | GPR142 (0.34) | KCNH2SCN9ASCN5AROCK2ROCK1 | |
| SCHEMBL14480615 | 0.73 | KCNH2 (0.47) | KCNH2SCN9ASCN1ASCN4ASCN5A | |
| SCHEMBL14480714 | 0.72 | ROCK2 (0.69) | KCNH2SCN9ASCN1ASCN4ASCN5A | |
| SCHEMBL21829052 | 0.72 | KCNH2 (0.46) | KCNH2SCN9ASCN1ASCN4ASCN5A | |
| SCHEMBL25955625 | 0.72 | PDE10A (0.35) | KCNH2SCN9ASCN1ASCN4ASCN5A | |
| SCHEMBL22563253 | 0.71 | ROCK2 (0.46) | KCNH2SCN9ASCN1ASCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |