Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 18/20 | 0.55 |
| ▸ | HTR2B | P41595 | 16/20 | 0.55 |
| ▸ | HTR2A | P28223 | 15/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14481143 | 1.00 | HTR2C (0.55) | HTR2CHTR2BHTR2AHTR6AXL | |
| SCHEMBL14481562 | 1.00 | HTR2C (0.55) | HTR2CHTR2BHTR2AHTR6AXL | |
| SCHEMBL13595220 | 0.91 | HTR2C (0.66) | HTR2CHTR2BHTR2AHTR6AXL | |
| Hydrochloric Acid SCHEMBL4408432 | 0.90 | HTR2C (0.65) | HTR2CHTR2BHTR2AHTR6AXL | |
| SCHEMBL13595236 | 0.87 | HTR2C (0.49) | HTR2CHTR2BHTR2AAXL | |
| Hydrochloric Acid SCHEMBL4408449 | 0.86 | HTR2C (0.48) | HTR2CHTR2BHTR2AAXL | |
| SCHEMBL14480619 | 0.84 | AR (0.43) | HTR2CHTR2BHTR2A | |
| SCHEMBL14481095 | 0.84 | AR (0.43) | HTR2CHTR2BHTR2A | |
| SCHEMBL21780397 | 0.84 | AR (0.43) | HTR2CHTR2BHTR2A | |
| SCHEMBL14480792 | 0.83 | ROCK2 (0.39) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |