Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19145317 | 0.88 | OPRM1 (0.50) | OPRM1OPRL1AOC3PDE5APIK3CA | |
| SCHEMBL19105592 | 0.83 | OPRM1 (0.49) | OPRM1OPRL1AOC3PDE5APIK3CA | |
| SCHEMBL21768428 | 0.82 | OPRM1 (0.48) | OPRM1OPRL1AOC3PDE5APIK3CA | |
| SCHEMBL26342031 | 0.78 | OPRM1 (0.44) | OPRM1OPRL1AOC3PDE5APIK3CA | |
| SCHEMBL25075257 | 0.76 | AOC3 (0.44) | OPRM1OPRL1AOC3ADRB1HPGDS | |
| SCHEMBL26352347 | 0.73 | AOC3 (0.43) | OPRM1OPRL1AOC3PIK3CAMTOR | |
| SCHEMBL22538528 | 0.72 | OPRL1 (0.46) | OPRL1KDM4ENR1H2NR1H3 | |
| SCHEMBL21780754 | 0.72 | OPRM1 (0.48) | OPRM1OPRL1AOC3PIK3CAMTOR | |
| SCHEMBL15415745 | 0.72 | ADRB1 (0.39) | OPRM1OPRL1AOC3PIK3CAMTOR | |
| SCHEMBL19117494 | 0.71 | AOC3 (0.49) | OPRM1OPRL1AOC3PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3402781-B1 | 3-((HETERO-)ARYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-03-04 | — | — | EP | disclosed |