Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16664161 | 0.91 | HCAR3 (0.44) | HCAR3ARDRD2DRD3AOC3 | |
| SCHEMBL9924584 | 0.83 | GBA1 (0.48) | AOC3CRHR1GBA1 | |
| SCHEMBL21769443 | 0.74 | HCAR3 (0.33) | HCAR3 | |
| SCHEMBL20056973 | 0.73 | HCAR3 (0.57) | HCAR3ARDRD2DRD3AOC3 | |
| SCHEMBL179289 | 0.72 | AOC3 (0.35) | HCAR3AOC3GBA1 | |
| SCHEMBL16646632 | 0.72 | HCAR3 (0.44) | HCAR3ARDRD2DRD3AOC3 | |
| SCHEMBL46324 | 0.70 | MEN1 (0.37) | — | |
| SCHEMBL2629280 | 0.69 | POLB (0.35) | HCAR3GBA1 | |
| SCHEMBL2629283 | 0.69 | HRH3 (0.44) | HCAR3 | |
| SCHEMBL20038496 | 0.69 | CRHR1 (0.42) | HCAR3CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3402781-B1 | 3-((HETERO-)ARYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-03-04 | — | — | EP | disclosed |