Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18399550 | 1.00 | ABL1 (0.41) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL22138739 | 1.00 | ABL1 (0.41) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL19059972 | 1.00 | ABL1 (0.41) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL20368679 | 1.00 | ABL1 (0.41) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL19059992 | 1.00 | ABL1 (0.41) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL24832244 | 1.00 | ABL1 (0.41) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL22853568 | 1.00 | ABL1 (0.41) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL21158392 | 1.00 | ABL1 (0.41) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL18399549 | 0.93 | LMNA (0.39) | ABL1SMN1; SMN2HTTALOX15HDAC3 | |
| SCHEMBL22138631 | 0.86 | ADRA2A (0.37) | ABL1SMN1; SMN2HTTLMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945939-B1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2020-03-04 | — | — | EP | disclosed |