Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SDCBP | O00560 | 2/20 | 0.36 |
| ▸ | SDC2 | P34741 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179912 | 0.92 | LMNA (0.48) | MAPTGAALMNATHRBTP53 | |
| SCHEMBL2179818 | 0.91 | LMNA (0.44) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL13719256 | 0.91 | LMNA (0.44) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL2179560 | 0.91 | NPC1 (0.51) | MEN1KMT2ALMNATHRBTP53 | |
| SCHEMBL2180394 | 0.86 | HTR2A (0.40) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL2178455 | 0.86 | LMNA (0.40) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL2224009 | 0.86 | HTR2A (0.40) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL2223220 | 0.85 | LMNA (0.47) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL2180501 | 0.85 | LMNA (0.47) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL2179349 | 0.84 | CSGALNACT1 (0.43) | MAPTLMNATHRBTP53KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |