Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180394 | 1.00 | HTR2A (0.40) | HTR2AHTR2CLMNATP53DGAT1 | |
| SCHEMBL2177914 | 0.92 | DGAT1 (0.44) | HTR2AHTR2CLMNATP53DGAT1 | |
| SCHEMBL13718763 | 0.92 | DGAT1 (0.44) | HTR2AHTR2CLMNATP53DGAT1 | |
| SCHEMBL2178261 | 0.86 | MAPT (0.43) | HTR2AHTR2CLMNATP53DGAT1 | |
| SCHEMBL2180429 | 0.85 | LMNA (0.43) | LMNATP53DGAT1THRBMEN1 | |
| SCHEMBL2178455 | 0.84 | LMNA (0.40) | HTR2AHTR2CLMNATP53DGAT1 | |
| SCHEMBL2176926 | 0.81 | DGAT1 (0.43) | LMNATP53DGAT1THRBMAPT | |
| SCHEMBL13718779 | 0.81 | DGAT1 (0.43) | LMNATP53DGAT1THRBMAPT | |
| SCHEMBL2177496 | 0.80 | KDR (0.42) | LMNADGAT1KDRMEN1KMT2A | |
| SCHEMBL2364244 | 0.80 | KDR (0.42) | LMNADGAT1KDRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |