Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 9/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.35 |
| ▸ | TSHR | P16473 | 9/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634018 | 0.87 | MEN1 (0.39) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL19634258 | 0.81 | HTR2A (0.38) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL20256741 | 0.79 | KMT2A (0.35) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL21783377 | 0.79 | MEN1 (0.37) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL31018047 | 0.78 | TP53 (0.39) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL21783443 | 0.78 | TP53 (0.39) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL21783444 | 0.78 | KMT2A (0.37) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL21794007 | 0.76 | GAA (0.42) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL21783395 | 0.76 | KMT2A (0.36) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL19634006 | 0.75 | DHFR (0.36) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047323-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |