Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22456387 | 0.81 | RIPK1 (0.50) | RIPK1RAB9AMAPTBCAT2SMN1; SMN2 | |
| SCHEMBL18921533 | 0.81 | RIPK1 (0.50) | RIPK1RAB9AMAPTBCAT2SMN1; SMN2 | |
| SCHEMBL22232743 | 0.81 | RIPK1 (0.50) | RIPK1RAB9AMAPTBCAT2SMN1; SMN2 | |
| SCHEMBL20580231 | 0.81 | BCAT2 (0.49) | RIPK1RAB9ABCAT2SMN1; SMN2LMNA | |
| SCHEMBL20580230 | 0.81 | BCAT2 (0.49) | RIPK1RAB9ABCAT2SMN1; SMN2LMNA | |
| SCHEMBL22232741 | 0.71 | RIPK1 (0.49) | RIPK1RAB9ABCAT2SMN1; SMN2LMNA | |
| SCHEMBL28673428 | 0.71 | POLB (0.50) | RIPK1RAB9AMAPTBCAT2SMN1; SMN2 | |
| SCHEMBL22232745 | 0.71 | RIPK1 (0.49) | RIPK1RAB9ABCAT2SMN1; SMN2LMNA | |
| SCHEMBL13021174 | 0.71 | MEN1 (0.68) | GAAMAPTHPGDHTTNPC1 | |
| Hydrochloric Acid SCHEMBL27556014 | 0.70 | MEN1 (0.66) | GAAMAPTHPGDHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020043173-A1 | HETEROCYCLIC COMPOUND AS RECEPTOR INTERACTING PROTEIN 1(RIP1) KINASE INHIBITOR | 宁波文达医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |