Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 16/20 | 0.76 |
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.76 |
| ▸ | DCLK1 | O15075 | 10/20 | 0.76 |
| ▸ | BRD4 | O60885 | 6/20 | 0.76 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.76 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.54 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.54 |
| ▸ | DCLK2 | Q8N568 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.54 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16065687 | 0.86 | MAPK7 (1.00) | MAPK7LRRK2DCLK1BRD4BRDT | |
| SCHEMBL29375286 | 0.86 | MAPK7 (1.00) | MAPK7LRRK2DCLK1BRD4BRDT | |
| SCHEMBL29538109 | 0.86 | MAPK7 (1.00) | MAPK7LRRK2DCLK1BRD4BRDT | |
| SCHEMBL16065728 | 0.80 | LRRK2 (1.00) | MAPK7LRRK2DCLK1BRD4BRDT | |
| SCHEMBL19425978 | 0.79 | LRRK2 (0.76) | MAPK7LRRK2DCLK1BRD4BRDT | |
| SCHEMBL21473578 | 0.79 | MAPK7 (0.63) | MAPK7LRRK2DCLK1BRD4BRDT | |
| SCHEMBL20628577 | 0.78 | MAPK7 (0.61) | MAPK7LRRK2DCLK1BRD4BRDT | |
| SCHEMBL17465830 | 0.77 | LRRK2 (0.85) | MAPK7LRRK2DCLK1BRD4BRDT | |
| SCHEMBL619121 | 0.77 | LRRK2 (1.00) | MAPK7LRRK2DCLK1BRD4TNK2 | |
| SCHEMBL24239838 | 0.76 | MAPK7 (1.00) | MAPK7LRRK2DCLK1BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115386-A1 | PYRIMIDINE SEVEN-MEMBERED-RING COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF | Anhui New Star Pharmaceutical Development Co., Ltd . (CN) | 2020-04-16 | — | — | US | disclosed |
| US-20200071340-A1 | PYRIMIDO-DIAZEPINONE COMPOUNDS AND METHODS OF TREATING DISORDERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071340-A1 | PYRIMIDO-DIAZEPINONE COMPOUNDS AND METHODS OF TREATING DISORDERS | BRSK2, GRK3, BRSK1 | MAPK7 292/4885LRRK2 324/4885DCLK1 483/4885 |
| US-20200115386-A1 | PYRIMIDINE SEVEN-MEMBERED-RING COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF | MST1, STK11, MSTN | MAPK7 112/4885LRRK2 143/4885DCLK1 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.