MSTN

Growth/differentiation factor 8 · O14793 · MSTN on Sugi Atlas →

26 patent compounds predicted against MSTN, 10 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL29655874 SCHEMBL29655874 0.59 1/20
SCHEMBL21374404 SCHEMBL21374404 0.54 1/20
SCHEMBL29607029 SCHEMBL29607029 0.53 1/20
SCHEMBL31321069 SCHEMBL31321069 0.52 1/20
SCHEMBL26929028 SCHEMBL26929028 0.48 1/20
SCHEMBL29403556 SCHEMBL29403556 0.48 1/20
SCHEMBL29484633 SCHEMBL29484633 0.47 1/20
SCHEMBL16509058 SCHEMBL16509058 0.44 1/20
Endothelin Endothelin (SCHEMBL29352622) 0.44 1/20
SCHEMBL23485427 SCHEMBL23485427 0.43 1/20

Clinical trials — most relevant to MSTN by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit PHASE2/PHASE3WITHDRAWN
A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy PHASE3ACTIVE_NOT_RECRUITING
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor PHASE1/PHASE2COMPLETED
Myostatin and Irisin Levels in Predicting the Outcome of Patients With Systemic Inflammation: A Prospective Observational Study nanCOMPLETED
ACTLIFE: is Active Life-style Enough? nanUNKNOWN
The Effect of Blood Flow Restriction (Bfr) Exercise on Acute Systemic Myokine Levels in Healthy Trained Men nanUNKNOWN
Personalized Medicine for SMA: a Translational Project nanUNKNOWN
Semmelweis Esophageal Cancer Study: Noninvasive Prognostic Parameters in Patients With Oesophageal and Esophagogastric Junction Cancer nanRECRUITING
Influence of Sarcopenia on the Course of the Diseases nanRECRUITING
Muscle in Acromegaly and Cushing's Syndrome nanUNKNOWN
Role of Myostatin, Activin A and Follistatin Cachexia of ENT Cancers nanCOMPLETED
Vitamin D Supplementation on Surrogate Markers of Ageing, Ageing Genes, Glycemic and Metabolic Markers in North India nanUNKNOWN
Comparison of Serum Myokine Dosages and Imaging Methods in the Evaluation of Sarcopenia in Patients With Hepatocellular Carcinoma nanRECRUITING
Serum Myostatin and Irisin Levels in Postmenopausal Women: Association With Bone Mineral Density and Muscle Strength nanNOT_YET_RECRUITING
Feasibility of VIIT in Adults With NASH nanCOMPLETED
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract nanUNKNOWN
Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation After Liver Transplantation nanCOMPLETED
Mediating Role of Myokines in the Dialogue Between Muscle and Bone Tissue in a Population of Healthy Women Aged 20-89 Years nanRECRUITING
Beta-Hydroxy-Beta-Methylbutyrate Supplementation and Physical Activity in Liver Cirrhosis: a Controlled Trial nanUNKNOWN
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle nanUNKNOWN
Combined Training (Strength and Endurance) and the Serum Levels of Myostatin and Hormone-sensitive Lipase in Overweight and Obese Men nanCOMPLETED
The Influence of Daily Grapes Intake on Sarcopenia in Postmenopausal Women nanCOMPLETED
Clinical Study to Evaluate Safety and Efficacy of Amino Acid in Healthy Individuals nanCOMPLETED
Impacts of Resistance Training on Acute Secretion of Irisin in Obese Older and Young Adults nanCOMPLETED
Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients nanCOMPLETED
In Vivo Analysis of Muscle Stem Cells in Chronic and Acute Lower Limb Ischemia (MyostemIschemia) nanCOMPLETED
Role of Activin A (ActA) in the Human Cancer Cachexia nanCOMPLETED
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise nanCOMPLETED
Effects of Growth Hormone (GH) Deficiency and Growth Hormone Replacement on Serum Fibroblast Growth Factor 21 (FGF21) nanWITHDRAWN
Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study nanENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a MSTN binder may also engage these)

ProteinNameSimilarity
O35312 1.000 O35312 →
A1C2U7 1.000 A1C2U7 →
Q8UWD9 1.000 Q8UWD9 →
Q5USV8 1.000 Q5USV8 →
A1C2V5 1.000 A1C2V5 →
O18830 1.000 O18830 →
O08689 1.000 O08689 →
Q5USW1 1.000 Q5USW1 →
Q5USV7 1.000 Q5USV7 →
A1C2U3 1.000 A1C2U3 →
A1C2V0 1.000 A1C2V0 →
Q95J86 1.000 Q95J86 →
O18828 1.000 O18828 →
O18831 1.000 O18831 →
Q6J1J2 1.000 Q6J1J2 →
Q8AVB2 1.000 Q8AVB2 →
Q6UKZ8 1.000 Q6UKZ8 →
Q5USW0 1.000 Q5USW0 →
Q6DTL9 1.000 Q6DTL9 →
O42221 1.000 O42221 →
A1C2U6 1.000 A1C2U6 →
O42220 1.000 O42220 →
Q8UWD7 1.000 Q8UWD7 →
Q8HY52 1.000 Q8HY52 →
O18836 1.000 O18836 →
Q5RZV4 1.000 Q5RZV4 →
Q5USV6 1.000 Q5USV6 →
Q5USV9 1.000 Q5USV9 →
O42222 1.000 O42222 →
Q6X5V1 0.999 Q6X5V1 →