Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SDCBP | O00560 | 2/20 | 0.40 |
| ▸ | SDC2 | P34741 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2178856 | 0.93 | LMNA (0.43) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2179927 | 0.91 | KDM4E (0.45) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2177992 | 0.91 | ITGB3 (0.46) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2177997 | 0.91 | ITGB3 (0.46) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2178572 | 0.90 | KDM4E (0.41) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2180852 | 0.90 | KDM4E (0.41) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2180255 | 0.90 | LMNA (0.51) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2180319 | 0.88 | MAPT (0.47) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2181321 | 0.87 | ABCB1 (0.45) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2181097 | 0.86 | TP53 (0.45) | LMNATP53ITGB3ITGA2BITGA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | claimed |
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |