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SCHEMBL21786463

SCHEMBL21786463

Oc1c(-c2cc(C(F)(F)F)[nH]n2)ccc(OCc2ccc(Cl)cc2)c1Cc1ccccc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5AP P20292 1/20 0.43
▸ TP53 P04637 2/20 0.41
▸ ALOX15 P16050 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ MAPT P10636 2/20 0.35
▸ GAA P10253 2/20 0.35
▸ HPGD P15428 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ THRB P10828 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ PTGER1 P34995 6/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ NPBWR1 P48145 1/20 0.34
▸ MCHR1 Q99705 1/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ MRGPRX4 Q96LA9 1/20 0.33
▸ MCL1 Q07820 1/20 0.33
▸ CARM1 Q86X55 1/20 0.33
▸ PRMT1 Q99873 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21786587 0.84 ALOX15 (0.46) ALOX5APTP53ALOX15MAPK1HSD17B10
SCHEMBL21786596 0.78 MRGPRX4 (0.44) TP53ALOX15MAPK1HSD17B10MRGPRX4
SCHEMBL21786631 0.78 HPGD (0.39) ALOX5APTP53ALOX15MAPK1HSD17B10
SCHEMBL21786447 0.77 GYS1 (0.39) ALOX5APTP53ALOX15MAPK1HSD17B10
SCHEMBL21786418 0.77 MRGPRX4 (0.43) ALOX5APTP53ALOX15MAPK1HSD17B10
SCHEMBL21786588 0.77 MRGPRX4 (0.39) ALOX5APTP53ALOX15MAPK1HSD17B10
SCHEMBL21786628 0.77 SLC6A4 (0.40) ALOX5APTP53ALOX15MAPK1HSD17B10
SCHEMBL21786629 0.77 MRGPRX4 (0.41) TP53ALOX15MAPK1HSD17B10MAPT
SCHEMBL21786417 0.77 ALOX5AP (0.37) ALOX5APTP53ALOX15MAPK1HSD17B10
SCHEMBL21786408 0.76 HPGD (0.45) ALOX5APTP53ALOX15MAPK1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210395206-A1 SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS NORTHWESTERN UNIVERSITY 2021-12-23 — — US disclosed
US-11142504-B2 Substituted heterocycles as c-MYC targeting agents NORTHWESTERN UNIVERSITY (US) 2021-10-12 — — US disclosed
WO-2020257261-A1 SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS NORTHWESTERN UNIVERSITY (US) 2020-12-24 — — WO disclosed
US-20200392116-A1 SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS NORTHWESTERN UNIVERSITY (US) 2020-12-17 — — US disclosed
WO-2020046382-A1 SUBSTITUTED HETEROCYCLES AS C-MYC TARGETING AGENTS NORTHWESTERN UNIVERSITY (US) 2020-03-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200392116-A1 SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS MYC, MYCBP, MYCBP2 ALOX5AP 4567/4885TP53 5/4885ALOX15 4648/4885
US-20210395206-A1 SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS MYC, MYCBP, MYCBP2 ALOX5AP 4567/4885TP53 5/4885ALOX15 4648/4885
US-11142504-B2 Substituted heterocycles as c-MYC targeting agents MYC, MYCBP, MYCBP2 ALOX5AP 4567/4885TP53 5/4885ALOX15 4648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.