Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777424 | 0.81 | KMT2A (0.41) | KMT2AALDH1A1KDM4EALOX15TDP1 | |
| SCHEMBL21787513 | 0.81 | KMT2A (0.41) | KMT2AALDH1A1KDM4EALOX15TDP1 | |
| SCHEMBL3622900 | 0.78 | NLRP3 (0.48) | KMT2AALDH1A1KDM4EALOX15TDP1 | |
| SCHEMBL8437061 | 0.76 | EPHX2 (0.49) | KMT2AALDH1A1PIN1POLBTSHR | |
| SCHEMBL5736978 | 0.75 | KMT2A (0.50) | KMT2AALDH1A1KDM4EALOX15TDP1 | |
| SCHEMBL4035939 | 0.75 | MMP8 (0.49) | KMT2AALDH1A1TDP1PIN1TSHR | |
| SCHEMBL30116829 | 0.75 | EED (0.38) | ALDH1A1KDM4ESMN1; SMN2GAAHPGD | |
| SCHEMBL3953513 | 0.74 | EED (0.40) | ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL9780837 | 0.74 | KMT2A (0.49) | KMT2AALDH1A1KDM4EALOX15TDP1 | |
| SCHEMBL9780828 | 0.74 | KMT2A (0.49) | KMT2AALDH1A1KDM4EALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047207-A1 | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN | MORPHIC THERAPEUTICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |