Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | TET3 | O43151 | 4/20 | 0.39 |
| ▸ | FBXL19 | Q6PCT2 | 4/20 | 0.39 |
| ▸ | CXXC5 | Q7LFL8 | 4/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.39 |
| ▸ | CXXC4 | Q9H2H0 | 4/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 3/20 | 0.39 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23328300 | 0.85 | CYP2D6 (0.39) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL28201825 | 0.82 | GPR183 (0.54) | GPR183TEAD3S1PR1S1PR3S1PR5 | |
| SCHEMBL23328306 | 0.78 | TEAD3 (0.35) | GPR183KMT2ATET3FBXL19CXXC5 | |
| SCHEMBL21787313 | 0.78 | CYP2D6 (0.54) | CYP2D6USP2CYP2C19 | |
| SCHEMBL24508582 | 0.78 | HRH2 (0.41) | S1PR1S1PR3S1PR5S1PR4DRD2 | |
| SCHEMBL24173124 | 0.76 | GNAI3 (0.49) | GPR183TEAD3S1PR1S1PR3S1PR5 | |
| SCHEMBL22856547 | 0.76 | S1PR1 (0.46) | S1PR1S1PR3S1PR5S1PR4CYP2D6 | |
| SCHEMBL11293146 | 0.74 | GPR183 (0.40) | GPR183TEAD3S1PR1S1PR3S1PR5 | |
| SCHEMBL22296239 | 0.74 | USP2 (0.45) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL23945646 | 0.73 | L3MBTL1 (0.54) | KMT2AS1PR1S1PR3S1PR5S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264499-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |