Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.81 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.74 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21790291 | 1.00 | ROCK2 (0.81) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21790243 | 0.92 | ROCK2 (0.70) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21795342 | 0.92 | ROCK2 (0.70) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21790248 | 0.90 | ROCK2 (0.72) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21790240 | 0.90 | ROCK2 (0.72) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21795453 | 0.90 | ROCK2 (0.80) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21790244 | 0.90 | ROCK2 (0.80) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21790286 | 0.90 | ROCK2 (0.76) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21790292 | 0.90 | ROCK2 (0.76) | ROCK2ROCK1MYLK4 | |
| SCHEMBL113527 | 0.89 | ROCK2 (0.78) | ROCK2ROCK1MYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691950-B2 | Isoquinoline-steroid conjugates and uses thereof | AERIE PHARMACEUTICALS, INC. (US) | 2023-07-04 | — | — | US | disclosed |
| US-11059789-B2 | Isoquinoline-steroid conjugates and uses thereof | AERIE PHARMACEUTICALS, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200071275-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | ALCON INC. (CH) | 2020-03-05 | — | — | US | disclosed |
| WO-2020047496-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | AERIE PHARMACEUTICALS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071275-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | GRK1, TNK2, CYP11B2 | ROCK2 172/4885ROCK1 210/4885MYLK4 217/4885 |
| US-11059789-B2 | Isoquinoline-steroid conjugates and uses thereof | GRK1, TNK2, CYP11B2 | ROCK2 172/4885ROCK1 210/4885MYLK4 217/4885 |
| US-11691950-B2 | Isoquinoline-steroid conjugates and uses thereof | GRK1, TNK2, CYP11B2 | ROCK2 172/4885ROCK1 210/4885MYLK4 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.