Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 11/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13571271 | 0.85 | HDAC3 (0.45) | ALOX5HDAC3HDAC6KDRFLT1 | |
| SCHEMBL2177207 | 0.84 | MAPT (0.42) | ALOX5HDAC3HDAC6KDRNPC1 | |
| SCHEMBL2178270 | 0.82 | ALOX5 (0.43) | ALOX5HDAC3HDAC6KDRFLT1 | |
| SCHEMBL2175935 | 0.82 | ALOX5 (0.43) | ALOX5HDAC3HDAC6KDRFLT1 | |
| SCHEMBL2195228 | 0.81 | ALOX5 (0.42) | ALOX5HDAC3HDAC6KDRFLT1 | |
| SCHEMBL12544010 | 0.78 | ALOX5 (0.40) | ALOX5HDAC3HDAC6KDRFLT1 | |
| SCHEMBL30779384 | 0.78 | ALOX5 (0.40) | ALOX5HDAC3HDAC6KDRFLT1 | |
| SCHEMBL1330877 | 0.77 | MAPT (0.49) | ALOX5HDAC6KDRNPC1MAPT | |
| SCHEMBL3394316 | 0.72 | PIN1 (0.48) | HDAC6KDRNPC1 | |
| SCHEMBL12544218 | 0.71 | HDAC3 (0.47) | ALOX5HDAC3HDAC6KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519524-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | Hutchison Medipharma Limited (CN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011079804-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-07-07 | — | — | WO | disclosed |