Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.61 |
| ▸ | RET | P07949 | 7/20 | 0.61 |
| ▸ | MET | P08581 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21750981 | 0.85 | KDR (0.61) | KDRRETMETEGFRAXL | |
| SCHEMBL21265686 | 0.83 | KDR (0.69) | KDRRETMETEGFRAXL | |
| SCHEMBL21246953 | 0.83 | KDR (0.59) | KDRRETMETEGFR | |
| SCHEMBL23749325 | 0.79 | KDR (0.54) | KDRRETMETEGFRAXL | |
| SCHEMBL23749306 | 0.78 | KDR (0.58) | KDRRETMETEGFR | |
| SCHEMBL13955465 | 0.78 | FGFR2 (0.58) | KDRMETAXL | |
| SCHEMBL21793294 | 0.77 | KDR (0.68) | KDRRETMET | |
| SCHEMBL23749294 | 0.77 | KDR (0.56) | KDRRETMETEGFR | |
| SCHEMBL21751008 | 0.76 | RET (0.61) | KDRRETMETEGFR | |
| SCHEMBL30664551 | 0.76 | RET (0.61) | KDRRETMETEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020042972-A1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXANE AND QUINAZOLINE OR QUINOLINE COMPOUND, COMPOSITION AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |