Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | GLA | P06280 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27774016 | 0.83 | APP (0.60) | APPMMP9MMP8MAPTGAA | |
| SCHEMBL30515680 | 0.81 | APP (0.57) | APPMMP9MMP8MAPTGAA | |
| SCHEMBL11972713 | 0.78 | APP (0.54) | APPMMP9MMP8MAPTGAA | |
| SCHEMBL9676001 | 0.75 | PSMB8 (0.56) | MAPTKDM4ERAB9AALDH1A1PSMB8 | |
| SCHEMBL11753243 | 0.75 | APP (0.50) | APPMMP9MMP8MAPTGAA | |
| SCHEMBL872727 | 0.73 | APP (1.00) | APPMMP9MMP8MAPTGAA | |
| SCHEMBL13322727 | 0.72 | APP (0.69) | APPMMP9MMP8MAPTGAA | |
| SCHEMBL1851438 | 0.71 | PSMB8 (0.59) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL12203770 | 0.71 | GAA (0.64) | APPMMP9MMP8MAPTGAA | |
| SCHEMBL4713556 | 0.71 | KDM4E (0.51) | MAPTGAAKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020043880-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2020-03-05 | — | — | WO | disclosed |