Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13719176 | 0.93 | TRPV1 (0.42) | TRPV1SMN1; SMN2MAPTNPC1NFKB1 | |
| SCHEMBL2181260 | 0.93 | TRPV1 (0.42) | TRPV1SMN1; SMN2MAPTNPC1NFKB1 | |
| SCHEMBL2181898 | 0.91 | MEN1 (0.42) | SMN1; SMN2MAPTNPC1RAB9AITGB3 | |
| SCHEMBL2180852 | 0.89 | KDM4E (0.41) | TRPV1SMN1; SMN2MAPTPLK1ITGB3 | |
| SCHEMBL2178572 | 0.89 | KDM4E (0.41) | TRPV1SMN1; SMN2MAPTPLK1ITGB3 | |
| SCHEMBL2179927 | 0.88 | KDM4E (0.45) | TRPV1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL2178856 | 0.84 | LMNA (0.43) | ITGB3ITGA2BITGA2KDM4ELMNA | |
| SCHEMBL2179919 | 0.84 | MEN1 (0.43) | SMN1; SMN2MAPTRAB9AITGB3ITGA2B | |
| SCHEMBL13719175 | 0.84 | MEN1 (0.43) | SMN1; SMN2MAPTRAB9AITGB3ITGA2B | |
| SCHEMBL2276572 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTNPC1NFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | claimed |
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |