Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | SDCBP | O00560 | 2/20 | 0.37 |
| ▸ | SDC2 | P34741 | 2/20 | 0.37 |
| ▸ | VHL | P40337 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2181260 | 0.91 | TRPV1 (0.42) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL13719176 | 0.91 | TRPV1 (0.42) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2228136 | 0.91 | SDCBP (0.36) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2284780 | 0.91 | SDCBP (0.36) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2283333 | 0.89 | SDCBP (0.36) | ALDH1A1HPGDSDCBPSDC2VHL | |
| SCHEMBL13572379 | 0.88 | SDCBP (0.38) | SDCBPSDC2VHLMAPK1 | |
| SCHEMBL2271028 | 0.85 | RARB (0.43) | SDCBPSDC2VHL | |
| SCHEMBL2179477 | 0.84 | TRPV1 (0.41) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2178926 | 0.83 | NPC1 (0.38) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2178932 | 0.83 | NPC1 (0.38) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |