Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | CYP8B1 | Q9UNU6 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23760701 | 1.00 | AR (0.42) | ARF2RL1CTSBJAK3HTT | |
| SCHEMBL18991731 | 0.92 | KDM4E (0.49) | F2RL1JAK3HTTKDM4EPDE3B | |
| SCHEMBL23760683 | 0.85 | MAP4K4 (0.42) | ARNCF1HTR2CPDE10APDE3B | |
| SCHEMBL23760669 | 0.82 | NOTUM (0.39) | ARHTTKDM4ENCF1HTR2C | |
| SCHEMBL21795314 | 0.82 | RBP4 (0.36) | ARNCF1PDE3BPDE3ACYP8B1 | |
| SCHEMBL18980205 | 0.80 | PIM2 (0.42) | NOTUMTLR7 | |
| SCHEMBL30571035 | 0.80 | PIM2 (0.42) | NOTUMTLR7 | |
| SCHEMBL30571038 | 0.80 | PIM2 (0.46) | — | |
| SCHEMBL28662001 | 0.80 | PIM2 (0.46) | — | |
| Hydrochloric Acid SCHEMBL23855279 | 0.79 | PIM2 (0.42) | NOTUMTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020043271-A1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-05 | — | — | WO | disclosed |