Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL290408 | 1.00 | — | — | |
| Bicarbonate SCHEMBL122180 | 0.94 | — | — | |
| Bicarbonate SCHEMBL138735 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL290407 | 0.88 | — | — | |
| Bicarbonate SCHEMBL8058353 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL231029 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL15955618 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL11420335 | 0.88 | — | — | |
| Bicarbonate SCHEMBL2504262 | 0.88 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL11685556 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100491552-C | Integrated ammoniacal solvent extraction and hydrogen reduction of nickel | QNI TECHNOLOGY PTY LTD (AU) | 2009-05-27 | — | — | CN | claimed |
| EP-1456427-B1 | INTEGRATED AMMONIACAL SOLVENT EXTRACTION AND HYDROGEN REDUCTION OF NICKEL | BHP BILLITON SSM TECH PTY LTD (AU) | 2008-07-02 | — | — | EP | claimed |
| US-7357827-B2 | Integrated ammoniacal solvent extraction and hydrogen reduction of nickel | QNI TECHNOLOGY PTY. LTD. (AU) | 2008-04-15 | — | — | US | claimed |
| EP-1456427-A4 | INTEGRATED AMMONIACAL SOLVENT EXTRACTION AND HYDROGEN REDUCTION OF NICKEL | QNI TECHNOLOGY PTY LTD (AU) | 2006-09-06 | — | — | EP | claimed |
| US-20050211022-A1 | Integrated ammoniacal solvent extraction and hydrogen reduction of nickel | QNI TECHNOLOGY PTY LTD. (AU) | 2005-09-29 | — | — | US | claimed |
| CN-1596317-A | Integrated ammoniacal solvent extraction and hydrogen reduction of nickel | QNI TECHNOLOGY PTY LTD (AU) | 2005-03-16 | — | — | CN | claimed |
| EP-1456427-A1 | INTEGRATED AMMONIACAL SOLVENT EXTRACTION AND HYDROGEN REDUCTION OF NICKEL | QNI Technology Pty Ltd (AU) | 2004-09-15 | — | — | EP | claimed |
| WO-2003046233-A1 | INTEGRATED AMMONIACAL SOLVENT EXTRACTION AND HYDROGEN REDUCTION OF NICKEL | QNI TECHNOLOGY PTY LTD (AU) | 2003-06-05 | — | — | WO | claimed |
| EP-4194085-A1 | METHOD FOR PREPARING AN OLIGOMERIZATION CATALYST COMPRISING A HYDROTHERMAL TREATMENT STEP | Evonik Operations GmbH (DE) | 2023-06-14 | — | — | EP | disclosed |
| US-20230173467-A1 | Process for producing an oligomerization catalyst having a hydrothermal treatment step | EVONIK OPERATIONS GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
| CN-110270337-B | Ni-containing catalyst for olefin oligomerization | 赢创运营有限公司 | 2023-05-26 | — | — | CN | disclosed |
| US-11253844-B2 | Oligomerization catalyst and process for the production thereof | EVONIK OPERATIONS GMBH (DE) | 2022-02-22 | — | — | US | disclosed |
| US-10882028-B2 | Ni-containing catalyst for the oligomerization of olefins | EVONIK OPERATIONS GMBH (DE) | 2021-01-05 | — | — | US | disclosed |
| US-10850261-B2 | Oligomerization catalyst and process for the production thereof | EVONIK OPERATIONS GMBH (DE) | 2020-12-01 | — | — | US | disclosed |
| US-7357827-B2 | Integrated ammoniacal solvent extraction and hydrogen reduction of nickel | QNI TECHNOLOGY PTY. LTD. (AU) | 2008-04-15 | — | — | US | disclosed |
| EP-1456427-A4 | INTEGRATED AMMONIACAL SOLVENT EXTRACTION AND HYDROGEN REDUCTION OF NICKEL | QNI TECHNOLOGY PTY LTD (AU) | 2006-09-06 | — | — | EP | disclosed |
| US-20050211022-A1 | Integrated ammoniacal solvent extraction and hydrogen reduction of nickel | QNI TECHNOLOGY PTY LTD. (AU) | 2005-09-29 | — | — | US | disclosed |
| CN-1596317-A | Integrated ammoniacal solvent extraction and hydrogen reduction of nickel | QNI TECHNOLOGY PTY LTD (AU) | 2005-03-16 | — | — | CN | disclosed |
| EP-1456427-A1 | INTEGRATED AMMONIACAL SOLVENT EXTRACTION AND HYDROGEN REDUCTION OF NICKEL | QNI Technology Pty Ltd (AU) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003046233-A1 | INTEGRATED AMMONIACAL SOLVENT EXTRACTION AND HYDROGEN REDUCTION OF NICKEL | QNI TECHNOLOGY PTY LTD (AU) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11253844-B2 | Oligomerization catalyst and process for the production thereof | C9, C5, C1S | CA4 1249/4885CA1 1403/4885FAHD1 2511/4885 |
| US-10850261-B2 | Oligomerization catalyst and process for the production thereof | C9, C5, C1S | CA4 1249/4885CA1 1403/4885FAHD1 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.