Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL5365144 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL9478094 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL9478602 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL6264226 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL2179596 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL89131 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL14125844 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL856 | 0.97 | — | — | |
| Malic Acid SCHEMBL256122 | 0.97 | — | — | |
| Malic Acid SCHEMBL98496 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4021663-A | — | — | None | — | — | JP | disclosed |
| JP-6287140-A | — | — | None | — | — | JP | disclosed |
| CN-119143744-A | Oxadiazole compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2024-12-17 | — | — | CN | disclosed |
| CN-113861178-B | Oxadiazole compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2024-09-13 | — | — | CN | disclosed |
| CN-117679563-B | Preparation method of piezoelectric modified collagen sponge with porous structure | 中国人民解放军总医院第四医学中心 | 2024-04-26 | — | — | CN | disclosed |
| CN-117679563-A | Preparation method of piezoelectric modified collagen sponge with porous structure | 中国人民解放军总医院第四医学中心 | 2024-03-12 | — | — | CN | disclosed |
| CN-115427038-A | Methods of treating nervous system symptoms associated with lysosomal storage diseases | 建新公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-111407721-A | A system for promoting penetration of active ingredients into skin | 复旦大学 | 2020-07-14 | — | — | CN | disclosed |
| CN-106465785-A | The removal methods of lead, cadmium in a kind of Semen phaseoli radiati albumen | 南昌大学 | 2017-03-01 | — | — | CN | disclosed |
| CN-106417889-A | Method for synchronously reducing contents of lead and cadmium in lotus seed protein | 南昌大学 | 2017-02-22 | — | — | CN | disclosed |
| CN-106387619-A | Method for synchronously reducing contents of lead and cadmium in pea protein through adsorption and substitution | 南昌大学 | 2017-02-15 | — | — | CN | disclosed |
| CN-106387299-A | Method for synchronously reducing contents of arsenic and copper in walnut protein | 南昌大学 | 2017-02-15 | — | — | CN | disclosed |
| CN-106279351-A | Arsenic, the method for copper content in simultaneous removing sunflower protein | 南昌大学 | 2017-01-04 | — | — | CN | disclosed |
| CN-105925072-A | Method for treating and modifying synthetic mica powder used for paint | 江阴市友佳珠光云母有限公司 | 2016-09-07 | — | — | CN | disclosed |
| CN-105017281-A | Salt of antofloxacin salt and preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2015-11-04 | — | — | CN | disclosed |
| EP-0883342-B1 | A COMPOSITION AND A METHOD FOR THE PROMOTION OF PLANT PRODUCTION AND/OR FOR THE ELIMINATION OF THE UNFAVOURABLE ENVIRONMENTAL INFLUENCES IN PLANT CULTIVATION | BIOREX KUTATO FEJLESZTOE KFT (HU) | 2001-10-10 | — | — | EP | disclosed |
| US-6268309-B1 | HYDROXIMIC ACID DERIVATIVE | Biorex Kutatóés FejlesztöRt. (HU) | 2001-07-31 | — | — | US | disclosed |
| WO-1996039126-A2 | RANITIDINE SALTS ON MAGNESIUM TRISILICATE AS AN ADSORBATE | WARNER-LAMBERT COMPANY (US) | 1996-12-12 | — | — | WO | disclosed |
| JP-H06287140-A | ANGINAL THERAPEUTIC AGENT CONTAINING DILTIAZEM AND MOLSIDOMINE | SYNTHELABO SA | 1994-10-11 | — | — | JP | disclosed |
| JP-H0421663-A | N-BENZYL-3-HYDROXYSUCCINAMIC ACID AND ITS PRODUCTION | KANEGAFUCHI CHEM IND CO LTD | 1992-01-24 | — | — | JP | disclosed |