Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19205657 | 1.00 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL18448917 | 0.90 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL19205758 | 0.90 | MEN1 (0.42) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL19205756 | 0.90 | MEN1 (0.42) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL19205763 | 0.86 | TRPV1 (0.40) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL21796351 | 0.86 | TRPV1 (0.40) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL21796354 | 0.82 | SMN1; SMN2 (0.40) | RAB9AMEN1KMT2ASMN1; SMN2RORC | |
| SCHEMBL18449664 | 0.82 | SMN1; SMN2 (0.40) | RAB9AMEN1KMT2ASMN1; SMN2RORC | |
| SCHEMBL18447581 | 0.81 | GAA (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL18448346 | 0.81 | RORC (0.50) | MEN1KMT2AMAPTNR2E1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331863-B1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2020-03-11 | — | — | EP | claimed |
| EP-3686187-A1 | PROCESS FOR THE PREPARATION OF ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2020-07-29 | — | — | EP | disclosed |