Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19205763 | 1.00 | TRPV1 (0.40) | TRPV1KCNJ5KCNJ3WNT3ARORC | |
| SCHEMBL19205595 | 0.90 | KCNJ5 (0.42) | TRPV1KCNJ5KCNJ3WNT3ARORC | |
| SCHEMBL19205594 | 0.90 | KCNJ5 (0.42) | TRPV1KCNJ5KCNJ3WNT3ARORC | |
| SCHEMBL21796350 | 0.88 | RIPK1 (0.40) | RORCRETMEN1KMT2ARIPK1 | |
| SCHEMBL19205749 | 0.88 | RIPK1 (0.40) | RORCRETMEN1KMT2ARIPK1 | |
| SCHEMBL22261805 | 0.88 | RORC (0.42) | RORCANO1RIPK1 | |
| SCHEMBL19205583 | 0.88 | RORC (0.42) | RORCANO1RIPK1 | |
| SCHEMBL21796353 | 0.86 | NPC1 (0.42) | RORCRETCYP2D6PSEN1PSEN2 | |
| SCHEMBL19205657 | 0.86 | NPC1 (0.42) | RORCRETCYP2D6PSEN1PSEN2 | |
| SCHEMBL18449666 | 0.85 | RORC (0.44) | TRPV1KCNJ5KCNJ3WNT3ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331863-B1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2020-03-11 | — | — | EP | claimed |
| EP-3686187-A1 | PROCESS FOR THE PREPARATION OF ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2020-07-29 | — | — | EP | disclosed |