Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | APOB | P04114 | 3/20 | 0.39 |
| ▸ | MTTP | P55157 | 3/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179993 | 0.91 | PTPRC (0.46) | LMNATP53PTPRCPDE3BPDE3A | |
| SCHEMBL2179986 | 0.91 | PTPRC (0.46) | LMNATP53PTPRCPDE3BPDE3A | |
| SCHEMBL2179020 | 0.90 | LMNA (0.42) | LMNATP53THRB | |
| SCHEMBL2178360 | 0.88 | LMNA (0.43) | LMNATP53THRBGAAATM | |
| SCHEMBL2181618 | 0.87 | LMNA (0.51) | LMNATP53GAAATMKCNK3 | |
| SCHEMBL2180791 | 0.87 | LMNA (0.48) | LMNATP53GAAATM | |
| SCHEMBL2180669 | 0.85 | LMNA (0.47) | LMNATP53GAAATM | |
| SCHEMBL2177933 | 0.85 | LMNA (0.41) | LMNATP53THRB | |
| SCHEMBL2179175 | 0.85 | TRPV4 (0.46) | LMNATP53THRBPTGESAPOB | |
| SCHEMBL2180255 | 0.84 | LMNA (0.51) | LMNATP53THRBGAAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | claimed |
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |