Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011865 | 0.70 | KDM4E (0.61) | KDM4EPKMGPR35DAOHCAR2 | |
| SCHEMBL23354437 | 0.69 | KDM4E (0.44) | KDM4EPKMGPR35DAOHCAR2 | |
| SCHEMBL3105240 | 0.69 | KDM4E (0.59) | KDM4EPKMDAOL3MBTL1TDP1 | |
| SCHEMBL4295731 | 0.67 | — | — | |
| SCHEMBL21542782 | 0.67 | — | — | |
| SCHEMBL4594949 | 0.67 | — | — | |
| SCHEMBL192563 | 0.67 | — | — | |
| SCHEMBL3559718 | 0.67 | — | — | |
| SCHEMBL2860777 | 0.67 | ABCC8 (0.42) | KDM4EGPR35HCAR2L3MBTL1EPHX2 | |
| Hydrochloric Acid SCHEMBL8624744 | 0.65 | KDM4E (0.96) | KDM4EPKMGPR35DAOHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277678-B1 | COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS | NANTBIO INC (US) | 2020-03-18 | — | — | EP | disclosed |