Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 13/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.52 |
| ▸ | HRH1 | P35367 | 5/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | HRH2 | P25021 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR1E | P28566 | 2/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23783113 | 0.95 | NAMPT (0.58) | NAMPTTMEM97SIGMAR1HRH1HRH3 | |
| SCHEMBL5455714 | 0.92 | NAMPT (0.53) | NAMPTTMEM97SIGMAR1HRH1HRH3 | |
| SCHEMBL34461170 | 0.86 | NAMPT (0.48) | NAMPTTMEM97SIGMAR1LNPEPPRMT5 | |
| SCHEMBL30366420 | 0.83 | NAMPT (0.52) | NAMPTTMEM97SIGMAR1HRH1HRH3 | |
| SCHEMBL21800336 | 0.83 | NAMPT (0.49) | NAMPTLNPEPPRMT5WDR77GRM5 | |
| SCHEMBL25201639 | 0.82 | NAMPT (0.50) | NAMPTTMEM97SIGMAR1LNPEPGRM5 | |
| SCHEMBL30582259 | 0.81 | LNPEP (0.48) | NAMPTTMEM97SIGMAR1LNPEPPRMT5 | |
| SCHEMBL31476781 | 0.80 | LNPEP (0.50) | NAMPTLNPEPPRMT5GRM5GRM1 | |
| SCHEMBL8195218 | 0.80 | NAMPT (0.57) | NAMPTPRMT5GRM5GRM1PDK4 | |
| SCHEMBL5473100 | 0.80 | NAMPT (0.65) | NAMPTGRM5GRM1PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3623369-B1 | NOVEL MORPHOLINYL AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2023-10-25 | — | — | EP | disclosed |
| EP-3623369-A1 | NOVEL MORPHOLINYL AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2020-03-18 | — | — | EP | disclosed |