Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23783113 | 0.94 | NAMPT (0.58) | NAMPTLNPEPPRMT5WDR77TMEM97 | |
| SCHEMBL21800337 | 0.92 | NAMPT (0.59) | NAMPTLNPEPPRMT5WDR77TMEM97 | |
| SCHEMBL34461170 | 0.89 | NAMPT (0.48) | NAMPTLNPEPPRMT5WDR77TMEM97 | |
| SCHEMBL14441055 | 0.86 | TMEM97 (0.48) | LNPEPTMEM97SIGMAR1GRM5ADRA2A | |
| SCHEMBL30366420 | 0.86 | NAMPT (0.52) | NAMPTLNPEPTMEM97SIGMAR1GRM5 | |
| SCHEMBL5459521 | 0.84 | LNPEP (0.48) | LNPEPTMEM97SIGMAR1GRM5ADRA2A | |
| SCHEMBL21800336 | 0.83 | NAMPT (0.49) | NAMPTLNPEPPRMT5WDR77GRM5 | |
| SCHEMBL25201639 | 0.83 | NAMPT (0.50) | NAMPTLNPEPTMEM97SIGMAR1GRM5 | |
| SCHEMBL5456989 | 0.82 | TMEM97 (0.61) | LNPEPTMEM97SIGMAR1ADRA2AADRA2B | |
| SCHEMBL30582259 | 0.81 | LNPEP (0.48) | NAMPTLNPEPPRMT5WDR77TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | CNR2, GRIN2C, GRIN2B | NAMPT 4183/4885LNPEP 3703/4885PRMT5 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.