Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21801346 | 0.86 | NR1H4 (0.31) | RETNR1H4 | |
| SCHEMBL29182339 | 0.83 | RET (0.35) | RETNR1H4 | |
| SCHEMBL21801350 | 0.81 | RET (0.36) | RETNR1H4 | |
| SCHEMBL21801379 | 0.81 | RET (0.34) | RETNR1H4 | |
| SCHEMBL29182312 | 0.77 | DGAT1 (0.37) | RETNR1H4 | |
| SCHEMBL30341066 | 0.77 | DGAT1 (0.37) | RETNR1H4 | |
| SCHEMBL29681783 | 0.76 | RET (0.33) | RET | |
| SCHEMBL21907256 | 0.76 | RET (0.33) | RET | |
| SCHEMBL21801354 | 0.76 | RET (0.39) | RET | |
| SCHEMBL30893385 | 0.74 | RET (0.41) | RETNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849986-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020055672-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2020-03-19 | — | — | WO | disclosed |