Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | ME2 | P23368 | 2/20 | 0.42 |
| ▸ | ME1 | P48163 | 2/20 | 0.42 |
| ▸ | ME3 | Q16798 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635047 | 0.87 | SMN1; SMN2 (0.47) | MAPTNPSR1LMNATSHRSMN1; SMN2 | |
| SCHEMBL19635460 | 0.85 | MRGPRX4 (0.42) | MAPTMAPK1GAALMNASMN1; SMN2 | |
| SCHEMBL19615270 | 0.84 | MEN1 (0.45) | MAPTNPSR1MAPK1GAATSHR | |
| SCHEMBL19635391 | 0.84 | MAPT (0.34) | MAPTNPSR1MAPK1ME2ME1 | |
| SCHEMBL19615367 | 0.82 | MEN1 (0.44) | MAPTMAPK1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28647264 | 0.78 | NR1H2 (0.39) | LMNASMN1; SMN2NPC1 | |
| SCHEMBL19615129 | 0.78 | NPC1 (0.38) | MAPTSMN1; SMN2NPC1ALDH1A1L3MBTL1 | |
| SCHEMBL21802216 | 0.78 | MAPT (0.43) | MAPTNPSR1MAPK1GAALMNA | |
| SCHEMBL21802201 | 0.75 | MAPT (0.37) | MAPTNPSR1MAPK1ME2ME1 | |
| SCHEMBL21802200 | 0.75 | MAPT (0.37) | MAPTNPSR1MAPK1ME2ME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10981932-B2 | Macrocyclic indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-20 | — | — | US | disclosed |
| US-20200087322-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981932-B2 | Macrocyclic indole derivatives | CCND2, IDO1, CCNT2 | MAPT 2202/4885NPSR1 1251/4885MAPK1 2106/4885 |
| US-20200087322-A1 | MACROCYCLIC INDOLE DERIVATIVES | CCND2, CCNA1, CCNT2 | MAPT 3026/4885NPSR1 1217/4885MAPK1 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.