Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ME2 | P23368 | 1/20 | 0.32 |
| ▸ | ME1 | P48163 | 1/20 | 0.32 |
| ▸ | ME3 | Q16798 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635460 | 0.86 | MRGPRX4 (0.42) | MAPTLMNAMAPK1SMN1; SMN2GAA | |
| SCHEMBL21802247 | 0.84 | MAPT (0.44) | MAPTTSHRLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL19615270 | 0.83 | MEN1 (0.45) | MAPTTSHRMAPK1SMN1; SMN2GAA | |
| SCHEMBL19615367 | 0.81 | MEN1 (0.44) | MAPTLMNAMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL19635047 | 0.80 | SMN1; SMN2 (0.47) | MAPTTSHRLMNASMN1; SMN2NPSR1 | |
| SCHEMBL24378074 | 0.80 | MAPT (0.39) | MAPTTSHRLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL19615129 | 0.76 | NPC1 (0.38) | MAPTSMN1; SMN2ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL19634874 | 0.73 | HRH3 (0.43) | MAPTTSHRLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL19615980 | 0.73 | PTGS2 (0.36) | — | |
| SCHEMBL21802224 | 0.73 | MCL1 (0.45) | MAPTTSHRLMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |