Sugi Predict

Sugi Predict / Compounds / SCHEMBL2180549

SCHEMBL2180549

SCHEMBL2180549

Oc1ccc(CCNc2ncnc3scnc23)c(F)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 6/20 0.39
▸ MKNK1 Q9BUB5 3/20 0.35
▸ PDE10A Q9Y233 1/20 0.35
▸ RAB9A P51151 3/20 0.34
▸ NR2F2 P24468 2/20 0.34
▸ PIP4K2C Q8TBX8 1/20 0.34
▸ CHRNA7 P36544 1/20 0.34
▸ TTBK1 Q5TCY1 1/20 0.34
▸ TTBK2 Q6IQ55 1/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ SMN1; SMN2 Q16637 3/20 0.33
▸ PI4KA P42356 1/20 0.33
▸ PI4K2B Q8TCG2 1/20 0.33
▸ PI4K2A Q9BTU6 1/20 0.33
▸ PI4KB Q9UBF8 1/20 0.33
▸ LMNA P02545 2/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ GALR3 O60755 1/20 0.32
▸ ADORA3 P0DMS8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12412302 0.86 HTT (0.38) HTTMKNK1PDE10ARAB9ANR2F2
SCHEMBL2181171 0.84 THRB (0.41) HTTMKNK1RAB9ANR2F2MEN1
SCHEMBL2178593 0.80 RAB9A (0.53) HTTRAB9ANR2F2PIP4K2CTTBK1
SCHEMBL12412286 0.79 HTT (0.41) HTTMKNK1RAB9ANR2F2PIP4K2C
SCHEMBL2177436 0.79 MAPT (0.38) HTTMKNK1RAB9ANR2F2MEN1
SCHEMBL12788918 0.79 HTT (0.40) HTTPDE10ARAB9ANR2F2CHRNA7
SCHEMBL12412278 0.78 SMN1; SMN2 (0.36) HTTMKNK1RAB9ANR2F2MEN1
SCHEMBL12340564 0.77 HTT (0.41) HTTPDE10ARAB9ANR2F2PIP4K2C
SCHEMBL2180855 0.77 MAP2K7 (0.32) MKNK1POLB
SCHEMBL2180019 0.75 NPC1 (0.37) RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8921382-B2 Thiazolo[5,4-d] pyrimidines and their use as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-12-30 — — US disclosed
US-8921382-B2 Thiazolo[5,4-d] pyrimidines and their use as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-12-30 — — US disclosed
US-8921382-B2 Thiazolo[5,4-d] pyrimidines and their use as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-12-30 — — US disclosed
EP-2521452-B1 THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2014-12-24 — — EP disclosed
EP-2521452-B1 THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2014-12-24 — — EP disclosed
WO-2011085084-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2011-07-14 — — WO disclosed
US-20110166164-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC 2011-07-07 — — US disclosed
US-20110166164-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC 2011-07-07 — — US disclosed
US-20110166164-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC 2011-07-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166164-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DPYD, TYMS, TYMP HTT 1922/4885MKNK1 3688/4885PDE10A 2125/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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