Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24027253 | 1.00 | ABCB1 (0.45) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL2529177 | 0.85 | ALDH1A1 (0.48) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL2529176 | 0.85 | ALDH1A1 (0.48) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5859962 | 0.84 | USP2 (0.43) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL27385307 | 0.84 | USP2 (0.43) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL21806029 | 0.84 | ABCB1 (0.46) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL24027198 | 0.84 | ABCB1 (0.46) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL29223471 | 0.83 | USP2 (0.50) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL16825817 | 0.81 | USP2 (0.49) | ABCB1USP2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL20232006 | 0.81 | USP2 (0.49) | ABCB1USP2SMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3853212-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF | Novartis AG (CH) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020058913-A1 | ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2020-03-26 | — | — | WO | disclosed |