Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528179 | 0.93 | NOS2 (0.49) | NOS2NOS3TYRTLR7TLR8 | |
| SCHEMBL6999496 | 0.82 | TYR (0.46) | TYRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL21776131 | 0.81 | TLR7 (0.42) | NOS2TLR7TLR8KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL28538588 | 0.79 | TYR (0.44) | TYRTLR8KDM4EMEN1USP2 | |
| SCHEMBL10456083 | 0.79 | TYR (0.44) | TYRKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL24228676 | 0.79 | TYR (0.44) | TYRKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL28052894 | 0.79 | TYR (0.44) | TYRKDM4EMEN1USP2ALDH1A1 | |
| Bromide SCHEMBL27953978 | 0.79 | TYR (0.44) | TYRTLR8KDM4EMEN1USP2 | |
| SCHEMBL28135505 | 0.79 | TYR (0.42) | NOS2TYRTLR8KDM4EMEN1 | |
| SCHEMBL11401202 | 0.77 | TLR8 (0.47) | NOS2NOS3TLR7TLR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3852736-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | Metacrine, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020061118-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| WO-2020061117-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| WO-2020061116-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |