Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 15/20 | 0.45 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29090320 | 0.84 | TRPC5 (0.46) | TRPC5TRPC4AR | |
| SCHEMBL29329165 | 0.84 | TRPC5 (0.47) | TRPC5TRPC4KMT2A | |
| SCHEMBL21807248 | 0.84 | TRPC5 (0.65) | TRPC5TRPC4 | |
| SCHEMBL29329169 | 0.83 | TRPC5 (0.45) | TRPC5TRPC4P2RX3P2RX2AR | |
| SCHEMBL21807320 | 0.83 | TRPC5 (0.44) | TRPC5TRPC4ARKMT2A | |
| SCHEMBL21807339 | 0.83 | TRPC5 (0.46) | TRPC5TRPC4 | |
| SCHEMBL31058992 | 0.83 | TRPC5 (0.46) | TRPC5TRPC4 | |
| SCHEMBL22002665 | 0.83 | TRPC5 (0.46) | TRPC5TRPC4 | |
| SCHEMBL29329276 | 0.83 | TRPC5 (0.44) | TRPC5TRPC4AR | |
| SCHEMBL20831591 | 0.82 | TRPC5 (0.41) | TRPC5TRPC4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941475-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | Goldfinch Bio, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-3852533-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | Goldfinch Bio, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020191056-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |
| WO-2020061162-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2020-03-26 | — | — | WO | disclosed |