SCHEMBL29329165

SCHEMBL29329165

O=c1c(Cl)c(N2CCc3c(ncnc3Sc3ccc(F)cc3C(F)(F)F)C2)cnn1C1CCCCO1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TRPC5 Q9UL62 18/20 0.47
TRPC4 Q9UBN4 2/20 0.47
PTPN11 Q06124 1/20 0.33
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29330277 0.91 TRPC5 (0.38) TRPC5TRPC4PTPN11
SCHEMBL29329396 0.91 TRPC5 (0.38) TRPC5TRPC4
SCHEMBL29090279 0.90 TRPC5 (0.37) TRPC5TRPC4
SCHEMBL29329548 0.88 TRPC5 (0.40) TRPC5TRPC4
SCHEMBL29090320 0.85 TRPC5 (0.46) TRPC5TRPC4
SCHEMBL29330069 0.85 TRPC5 (0.39) TRPC5TRPC4PTPN11
SCHEMBL21807248 0.84 TRPC5 (0.65) TRPC5TRPC4
SCHEMBL21807341 0.84 TRPC5 (0.45) TRPC5TRPC4KMT2A
SCHEMBL29329169 0.84 TRPC5 (0.45) TRPC5TRPC4KMT2A
SCHEMBL21807339 0.83 TRPC5 (0.46) TRPC5TRPC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4400500-A1 HALOGEN-SUBSTITUTED PYRIDAZINONE COMPOUND AND APPLICATION THEREOF Medshine Discovery Inc. (CN) 2024-07-17 EP disclosed