⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880937 | 0.75 | CUL4A (0.31) | — | |
| SCHEMBL8315513 | 0.73 | — | — | |
| SCHEMBL192325 | 0.70 | — | — | |
| SCHEMBL979388 | 0.70 | — | — | |
| SCHEMBL23531222 | 0.67 | — | — | |
| SCHEMBL25302090 | 0.67 | — | — | |
| SCHEMBL27543267 | 0.67 | DYRK1A (0.39) | — | |
| SCHEMBL28010060 | 0.67 | — | — | |
| SCHEMBL5321800 | 0.67 | TNF (0.34) | — | |
| SCHEMBL28246280 | 0.65 | KDM1A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3853220-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | Suzhou Zanrong Pharma Limited (CN) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020057511-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2020-03-26 | — | — | WO | disclosed |