Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 9/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.76 |
| ▸ | PGR | P06401 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | AR | P10275 | 2/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | APEX1 | P27695 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | IKBKB | O14920 | 1/20 | 0.76 |
| ▸ | CHUK | O15111 | 1/20 | 0.76 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.76 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.76 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.76 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexamethasone SCHEMBL4085868 | 1.00 | NR3C1 (0.76) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| Triamcinolone SCHEMBL5146078 | 0.94 | NR3C1 (0.75) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| Beclomethasone SCHEMBL16823398 | 0.94 | HIF1A (0.71) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| Dexamethasone SCHEMBL143971 | 0.94 | NR3C1 (0.77) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| Fludrocortisone Acetate SCHEMBL22472347 | 0.88 | HIF1A (0.74) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| Clobetasol SCHEMBL16099014 | 0.87 | NR3C1 (0.69) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| SCHEMBL3405133 | 0.87 | NR3C1 (0.72) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| SCHEMBL11317374 | 0.87 | NR3C1 (0.72) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| SCHEMBL11312637 | 0.87 | NR3C1 (0.72) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 | |
| SCHEMBL11324493 | 0.87 | NR3C1 (0.72) | NR3C1CYP3A4HIF1AHSD17B10NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3852719-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE COMPRISING AT LEAST ONE LOCAL ANAESTHETIC SUBSTANCE | Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC (FR) | 2021-07-28 | — | — | EP | disclosed |
| EP-3852726-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE COMPRISING AT LEAST ONE ANTI-INFLAMMATORY SUBSTANCE | Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC (FR) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020058605-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE COMPRISING AT LEAST ONE LOCAL ANAESTHETIC SUBSTANCE | SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) | 2020-03-26 | — | — | WO | disclosed |
| WO-2020058603-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE COMPRISING AT LEAST ONE ANTI-INFLAMMATORY SUBSTANCE | SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) | 2020-03-26 | — | — | WO | disclosed |