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Beclomethasone

Beclomethasone

SCHEMBL16823398

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HIF1A Q16665 9/20 0.71
▸ NR3C1 P04150 7/20 0.71
▸ CYP3A4 P08684 6/20 0.71
▸ NFKB1 P19838 4/20 0.71
▸ LMNA P02545 4/20 0.71
▸ ABCB11 O95342 2/20 0.71
▸ BLM P54132 2/20 0.71
▸ MAPT P10636 1/20 0.71
▸ GAA P10253 1/20 0.71
▸ SMN1; SMN2 Q16637 1/20 0.71
▸ HSD17B10 Q99714 4/20 0.67
▸ PGR P06401 4/20 0.67
▸ TSHR P16473 2/20 0.67
▸ AR P10275 2/20 0.67
▸ PMP22 Q01453 2/20 0.67
▸ MEN1 O00255 1/20 0.67
▸ CYP2D6 P10635 1/20 0.67
▸ KMT2A Q03164 1/20 0.67
▸ APEX1 P27695 1/20 0.67
▸ NPSR1 Q6W5P4 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betamethasone SCHEMBL21808820 0.94 NR3C1 (0.76) HIF1ANR3C1CYP3A4NFKB1LMNA
Dexamethasone SCHEMBL4085868 0.94 NR3C1 (0.76) HIF1ANR3C1CYP3A4NFKB1LMNA
Triamcinolone SCHEMBL5146078 0.88 NR3C1 (0.75) HIF1ANR3C1CYP3A4NFKB1LMNA
Dexamethasone SCHEMBL10583077 0.88 HIF1A (0.75) HIF1ANR3C1CYP3A4NFKB1LMNA
Dexamethasone SCHEMBL143971 0.88 NR3C1 (0.77) HIF1ANR3C1CYP3A4NFKB1LMNA
Beclomethasone SCHEMBL991782 0.87 HIF1A (0.89) HIF1ANR3C1CYP3A4NFKB1LMNA
Beclomethasone SCHEMBL8207142 0.85 HIF1A (0.84) HIF1ANR3C1CYP3A4NFKB1LMNA
Beclomethasone SCHEMBL12396658 0.84 HIF1A (1.00) HIF1ANR3C1CYP3A4NFKB1LMNA
SCHEMBL11312637 0.84 NR3C1 (0.72) HIF1ANR3C1CYP3A4NFKB1LMNA
Beclomethasone SCHEMBL5486747 0.84 HIF1A (1.00) HIF1ANR3C1CYP3A4NFKB1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015089559-A1 OPTIMISING BIOAVAILABILITY OF INTRA VITREALLY INJECTABLE STEROIDS EYE CO PTY LTD (AU) 2015-06-25 — — WO disclosed
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