Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 10/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.68 |
| ▸ | MAPT | P10636 | 9/20 | 0.68 |
| ▸ | APAF1 | O14727 | 6/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 9/20 | 0.55 |
| ▸ | MITF | O75030 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | CASP3 | P42574 | 3/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16997940 | 0.90 | HTT (0.59) | HTTALDH1A1MAPTAPAF1KMT2A | |
| SCHEMBL29892254 | 0.81 | HTT (1.00) | HTTALDH1A1MAPTAPAF1KMT2A | |
| SCHEMBL21808931 | 0.81 | HTT (1.00) | HTTALDH1A1MAPTAPAF1KMT2A | |
| SCHEMBL2808423 | 0.78 | NR4A2 (0.55) | HTTALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL21808989 | 0.78 | HTT (0.68) | HTTALDH1A1MAPTAPAF1KMT2A | |
| SCHEMBL16998411 | 0.78 | HTT (0.68) | HTTALDH1A1MAPTAPAF1KMT2A | |
| SCHEMBL21809001 | 0.77 | HTT (0.67) | HTTALDH1A1MAPTAPAF1KMT2A | |
| SCHEMBL16998405 | 0.77 | HTT (0.80) | HTTALDH1A1MAPTAPAF1KMT2A | |
| SCHEMBL23232542 | 0.75 | USP1 (0.46) | HTTALDH1A1MAPTAPAF1KMT2A | |
| SCHEMBL27883703 | 0.74 | MAPT (0.50) | HTTALDH1A1MAPTAPAF1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11919886-B2 | 4,9-dioxo-4,9-dihydronaphtho[2,3-B]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases | ACADEMIA SINICA (TW) | 2024-03-05 | — | — | US | disclosed |
| US-20230010562-A1 | 4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-3-CARBOXAMIDE DERIVATIVES AND USES THEREOF FOR TREATING PROLIFERATIVE DISEASES AND INFECTIOUS DISEASES | ACADEMIA SINICA (TW) | 2023-01-12 | — | — | US | disclosed |
| US-11434229-B2 | 4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases | ACADEMIA SINICA (TW) | 2022-09-06 | — | — | US | disclosed |
| US-20200095233-A1 | 4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-3-CARBOXAMIDE DERIVATIVES AND USES THEREOF FOR TREATING PROLIFERATIVE DISEASES AND INFECTIOUS DISEASES | ACADEMIA SINICA (TW) | 2020-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230010562-A1 | 4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-3-CARBOXAMIDE DERIVATIVES AND USES THEREOF FOR TREATING PROLIFERATIVE DISEASES AND INFECTIOUS DISEASES | DHODH, NQO2, PKD1 | HTT 3767/4885ALDH1A1 199/4885MAPT 4228/4885 |
| US-20200095233-A1 | 4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-3-CARBOXAMIDE DERIVATIVES AND USES THEREOF FOR TREATING PROLIFERATIVE DISEASES AND INFECTIOUS DISEASES | DHODH, NQO2, PKD1 | HTT 3767/4885ALDH1A1 199/4885MAPT 4228/4885 |
| US-11434229-B2 | 4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases | DHODH, NQO2, PKD1 | HTT 3767/4885ALDH1A1 199/4885MAPT 4228/4885 |
| US-11919886-B2 | 4,9-dioxo-4,9-dihydronaphtho[2,3-B]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases | DHODH, NQO2, PKD1 | HTT 3767/4885ALDH1A1 199/4885MAPT 4228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.